职 务：
职 称：青年研究员
电子邮箱：guoqp@lzu.edu.cn
科研方向：药物化学，多肽药物
郭全平，男，理学博士，yl6809永利新药设计与合成研究所青年研究员。2016年毕业于永利药学院药学专业，获理学学士学位；2016-2021年就读于yl6809永利生物化学与分子生物学专业，师从许兆青教授从事药物化学研究，获理学博士学位；2021年8月-2024年1月于西湖大学胡鹏飞教授课题组进行博士后研究，期间主要从事活性天然产物全合成及电化学合成方法学研究；2024年5月加入yl6809永利。以第一作者或通讯作者在国际著名期刊JACS、Nat. Commun.、Angew. Chem. Int. Ed.、ACS Catal.、Chem. Commun. Bioorg. Med. Chem.等杂志发表SCI论文10篇，授权发明专利1项。
教育经历：
2016.09-2021.06 yl6809永利，生物化学与分子生物学，博士
2012.09-2016.06 永利药学院，药学，学士
工作经历：
2021.08-2024.01 西湖大学理学院 博士后
2024.05-至今 yl6809永利新药设计与合成研究所，青年研究员
药物合成与修饰新方法开发、多肽药物研究。
已发表论文:
1. Peng. C.#; Guo, Q.#; Xu, G.#; Huo, L.; Wu, W.; Chen, T. -Y.; Hong, X.*, Hu, P.*, Divergent synthesis of Scabrolide A and Havellockate via an exo-exo-endo radical cascade. J. Am. Chem. Soc. 2024, 146, 14422−14426. (#co-first author)
2. Guo, Q.; Jiang, Y.; Zhu, R.; Yang, W.; Hu, P.* Electrochemical Azo-free Mitsunobu-type reaction. Angew. Chem. Int. Ed. 2024, 63, e202402878.
3. Li, Z.#; Wang, S.#; Huo, Y.; Wang, B.; Yan, J.; Guo, Q.* Visible light-driven fluoroalkylthiocyanation of alkenes via electron donor–acceptor complexes. Org. Chem. Front., 2021, 8, 3076–3081. (#co-first author).
4. Yao, H.#; Guo, Q.#; Wang, M.; Wang, R.*; Xu, Z.* Discovery of pyrazole N-aryl sulfonate: A novel and highly potent cyclooxygenase-2 (COX-2) selective inhibitors. Bioorg. Med. Chem. 2021, 46, 116344. (#co-first author)
5. Guo, Q.; Peng, Q.; Chai, H.; Huo, Y.; Wang, S.; Xu, Z.* Visible-light promoted regioselective amination and alkylation of remote C(sp3)-H bonds. Nat. Commun. 2020, 11, 1463.
6. Guo, Q.#; Wang, M.#; Peng, Q.; Huo, Y.; Liu, Q.; Wang, R.*; Xu, Z.* Dual-functional chiral Cu-catalyst-induced photoredox asymmetric cyanofluoroalkylation of alkenes. ACS Catal. 2019, 9, 4470-4476. (#co-first author)
7. Guo, Q.#; Wang, M.#; Liu, H.; Wang, R.*; Xu, Z.* Visible‐light‐promoted dearomative fluoroalkylation of β‐Naphthols through intermolecular charge transfer. Angew. Chem. Int. Ed. 2018, 57, 4747 –4751. (#co-first author)
8. Guo, Q.; Wang, M.; Wang, Y.; Xu, Z.*; Wang, R.*; Photoinduced, copper-catalyzed three components cyanofluoroalkylation of alkenes with fluoroalkyl iodides as fluoroalkylation reagents. Chem. Commun. 2017, 53, 12317-12320.
9. Liu, H.# Guo, Q.#; Chen, C.; Wang, M.; Xu, Z.* Photo-induced, Cu-catalyzed three component azidofluoroalkylation of alkenes with CF3I and RfI as fluoroalkylation reagents. Org. Chem. Front. 2018, 5, 1522-1526. (#co-first author)
10. Kong, W.#; Guo, Q.#; Xu, Z.*; Wang, G.; Jiang, X.*; Wang, R.* Iodine(III)-mediated oxy-fluorination of alkenyl oximes: An easy path to monofluoromethyl-substituted isoxazolines. Org. Lett. 2015, 17, 3686-3689. (#co-first author)
11. Wang, C.; Chen, Q.; Guo, Q.; Liu, H.; Xu, Z.* Liu, Y.; Wang, M.; Wang, R.* Silver-catalyzed difluoroamidation of activated alkenes for the construction of difluorinated 3,3-disubstituted oxindoles. J. Org. Chem. 2016, 81, 5782-5788.
12. Zhu, L.; Yu, H.; Guo, Q.; Chen, Q.; Xu, Z.*; Wang, R.* C–H bonds phosphorylation of ketene sithioacetals. Org. Lett. 2015, 17, 1978-1981.
13. Zhu, L.; Wang, G.; Guo, Q.; Xu, Z.*; Zhang, D.; Wang, R.*; Copper-catalyzed intramolecular oxytrifluoromethylthiolation of unactivated alkenes. Org. Lett. 2014, 16, 5390-5393.
已授权专利：
一种含有N-芳基磺酸酯的吡咯化合物的合成和运用。专利号：ZL201810199989.1
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