细胞代谢与免疫微环境，DNA损伤修复及肿瘤治疗

代表性论文：

1. Shen, R.; Yang, K.; Cheng, X.; Guo, C.; Xing, X.; Sun, H.; Liu, D.; Liu, X.; Wang, D. Accumulation of polystyrene microplastics induces liver fibrosis by activating cGAS/STING pathway. Environ Pollut. 2022, 300,118986.

2. Shen, R.; Liu, D.; Wang, X.; Guo, Z.; Sun, H.; Song, Y.; Wang, D. DNA damage and activation of cGAS/STING pathway induce tumor microenvironment remodeling. Front Cell Dev Biol. 2022, 9, 828657.

3. Shen, R.; Li, Y.; Yu, L.; Wu, H.; Cui, R.; Liu, S.; Song, Y.; Wang, D., Ex vivo detection of cadmium-induced renal damage by using confocal Raman spectroscopy. Journal of biophotonics. 2019, 12, e201900157.

4. Shen, R.; Liu, D.; Hou, C.; Liu, D.; Zhao, L.; Cheng, J.; Wang, D.; Bai, D., Protective effect of Potentilla anserina polysaccharide on cadmium-induced nephrotoxicity in vitro and in vivo. Food & function. 2017, 8, 3636-3646.

5. Shen, R.; Liu, D.; Hou, C.; Cheng, J.; Bai, D., New fluorescent probe for Zn2+ imaging in living cells and plants. Analytical Methods. 2015, 8, 2541-2541.

6. Guo, Y.#; Shen, R.#; Wang, F.; Wang, Y.; Xia, P.; Wu, R.; Liu, X.; Ye, W.; Tian, Y.; Wang,D. Carbon ion irradiation induces DNA damage in melanoma and optimizes the tumor icroenvironment based on the cGAS–STING pathway. J cancer res clin. 2023, 6.

7. Song, H.#, Shen, R.#, Liu, X, Yang, X, Xie, K, Guo, Z, Wang, D. Histone post-translational modification and the DNA damage response, Genes & Disease, 2023, Jul 10, 1429-1444

8. Wu, D. #; Li, J. #; Shen, R.#; Li, J.; Yu, Y.; Li, L.; Deng, S.; Liu, T.; Zhang, T.; Xu, Y.; Wng, D. Autophagy Induced by Micheliolide Alleviates Acute Irradiation-Induced Intestinal Injury via Inhibition of the NLRP3 Inflammasome. Front Pharmacol. 2022 Jan 18;12:773150.

9. Guo, Y. #; Shen, R. #; Yang, K.; Wang, Y., Song, H.; Liu, X.; Cheng, X.; Wu, R.; Song, Y.; Wang, D. RNF8 enhances the sensitivity of PD-L1 inhibitor against melanoma through ubiquitination of galectin-3 in stroma, Cell Death Discov, 2023 Jun 30;9(1):205.

10. Zhang, G.; Ji, P.; Xia, P.; Song, H.; Guo, Z.; Hu, X.; Guo, Y.; Yuan, X.; Song, Y.; Shen, R.*; Wang, D*. Identification and targeting of cancer-associated fibroblast signature genes for prognosis and therapy in Cutaneous melanoma, Comput Biol Med, 2023 Oct 18:167:107597.

11. Ji, P.; Zhang, G.; Guo, Y.; Song, H.; Yuan, X.; Hu, X.; Guo, Z.; Xia, P.; Shen, R.*; Wang, D*. Protein crotonylation: An emerging regulator in DNA damage response, Life Sci, 2023 Oct 15:331:122059.

12. Yu, L.#; Shen, R.#; Guo, Y.; Guo, Y.; Li, C.; Song, Y.*; Wang, D.* Loss of the ubiquitin-conjugating enzyme Rad6B disturbs mitochondrial function and cellular homeostasis in mouse skin, biocell, 2021, 45: 761-772.

13. Li, Y.#; Shen, R.#; Wu, H.; Yu, L.; Wang, Z.; Wang, D.* Liver changes induced by cadmium poisoning distinguished by confocal Raman imaging, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2020, 225, 117483.

14. Ye, Q.; Wang, J.; Liu, X.; Liu, Z.; BaZong, L.; Ma, J; Shen, R.*; Ye, W.*; Zhang, W.*; Wang, D.* The Role of RAD6B and PEDF in Retinal Degeneration, NEUROSCIENCE, 2022, 480: 19-31.

15. Ma, Y.#; Song, Y.#; Shen, R.#; Li, P.; Ding, H.; Guo, Z.; Liu, X.; Wang, D*. Loss of RAD6B induces degeneration of the cochlea in mice, Biochemical and Biophysical Research Communications, 2020, 531(3): 402-408.

16. Song, H.; Shen, R.; Mahasin, H.; Guo, Y.; Wang, D. DNA replication: Mechanisms and therapeutic interventions for diseases. MedComm. 2023, 5;4(1):e210.

17. Xia, P.; Ouyang, S.; Shen, R.; Guo, Z.; Zhang, G.; Liu, X.; Yang, X.; Xie, K.; Wang, D. Macrophage-Related Testicular Inflammation in Individuals with Idiopathic Non-Obstructive Azoospermia: A Single-Cell Analysis. Int mol sci. 2023, 16;24(10):8819.

18. Yanan Guo; Rong Shen; Linghui Yu; Xin Zheng; Rong Cui; Yanfeng Song; Degui Wang*; Roles of galectin‑3 in the tumor microenvironment and tumor metabolism, Oncology Reports, 2020, 44: 1799-1809.

19. Yang Yang; Yan Feng; Hao Li; Rong Shen; Yingzhe Wang; Xuerui Song; Chen Cao; Guolin Zhang*; Weisheng Liu*; Hydro-soluble NIR fluorescent probe with multiple sites and multiple excitations for distinguishing visualization of endogenous Cys/Hcy, and GSH, Sensors and Actuators: B. Chemical, 2020, 333.

20. Chunlin Sun; Jun Li; Xiaozhen Wang; Rong Shen; Sha Liu; Jianqiao Jiang; Ting Li; Qiwei Song; Qing Liao; Hongbing Fu*; Jiannian Yao*; HaoLi Zhang*; Rational Design of Organic Probes for Turn-On Two-Photon Excited Fluorescence Imaging and Photodynamic Therapy, Chem, 2019, 5(3): 600-616.

21. Yingzhe Wang; Boya Li; Xuerui Song; Rong Shen; Degui Wang; Yang Yang; Yan Feng; Cao Chen; Guolin Zhang*; Weisheng Liu*; Mito-Specific Ratiometric Terbium (III)-Complex-Based Luminescent Probe for Accurate Detection of Endogenous Peroxynitrite by Time-Resolved Luminescence Assay, Analytical Chemistry, 2019,91(19): 12422-12427.

22. Hong Huang; Tingyu Li; Yifan Sun; Linghui Yu; Changding Wang; Rong Shen; Weichun Ye*; Degui Wang; Yumin Li; Amperometric sensing of hydrazine in environmental and biological samples by using CeO2-encapsulated gold nanoparticles on reduced graphene oxide, Microchimica Acta, 2019, 186.

23. Yang Yang; Rong Shen; YingZhe Wang; FangZhou Qiu; Yan Feng; XiaoLiang Tang; DeCheng Bai; Guolin Zhang*; WeishengLiu*; A selective turn-on fluorescent sensor for Hg (II) in living cells and tissues, Sensors and Actuators B: Chemical, 2018, 255: 3479-3487.

24. Yaming Liu; Rong Shen; Jiaxi Ru; Xiang Yao; Yang Yang; Haile Liu; Xiaoliang Tang; Decheng Bai; Guolin Zhang*; Weisheng Liu*; A reversible rhodamine 6G-based fluorescence turn-on probe for Fe3 in water and its application in living cell imaging, RSC Advances, 2016, 6(113): 111754-111759.

25. Chunlin Sun; Qing Liao; Ting Li; Jun Li; Jianqiao Jiang; Zhenzhen Xu; Xuedong Wang; Rong Shen; Decheng Bai; Qiang Wang; Shengxiang Zhang; Hongbing Fu; Haoli Zhang*; Rational design of small indolic squaraine dyes with large two-photon absorption cross section, Chemical Science, 2015, 6(1): 761-769.

26. Kaiming Zhang; Wei Dou; Pengxuan Li; Rong Shen; Jiaxi Ru; Wei Liu; Yumei Cui; Chunyang Chen; Weisheng Liu*; Decheng Bai*; A coumarin-based two-photon probe for hydrogen peroxide, Biosensors and Bioelectronics, 2015, 64: 542-546.

27. Jun Li; Chunlin Sun; Rong Shen; Xiaoyan Cao; Bo Zhou; Decheng Bai*; Haoli Zhang*; An Electrochemically Switched Smart Surface for Peptide Immobilization and Conformation Control, Journal of the American Chemical Society, 2014, 136(31): 11050-11056.202, 333.

28. Fengjuan Chen; Guozhen Liu; Yanjun Shi; Pinxian Xi; Ju Cheng; Jinpeng Hong; Rong Shen; Xiaojun Yao; Decheng Bai; Zhengzhi Zeng*; A coumarin-derived fluorescent chemosensor for selectively detecting Cu2: Synthesis, DFT calculations and cell imaging applications, Talanta, 2014, 124: 139-145.

专利：

一种检测锌离子的荧光分子探针及其制备方法,2015-8-19,中国, ZL20141021567.8。

一种蕨麻总黄酮提取设备，2020-6-19，中国，ZL201910338979.6。

科研项目：

RNF8经调控galectin-3泛素化修饰影响黑色素瘤免疫微环境的机制研究，国家自然科学基金青年项目，2023.1-2025.12，主持，在研

裸鼹鼠、长爪沙鼠等五种特色实验动物的辐射损伤、代谢性紊乱、抗血吸虫病、帕金森病、脑缺血等疾病模型的创建及关键技术研究，科技部重点研发项目，2022.1-2026.11，参与，在研

RNF8 经 GAPDH 介导瘤内成纤维细胞代谢重编程影响黑色素瘤转移机制的研究，永利中央高校定向探索项目，2022.7-2024.6，主持，在研

当归补血汤抗放射性心肌损伤的物质基础及作用机制研究，甘肃省卫健委，2023.1-2026.12，参与，在研

RNF8在ACSL4介导的肝脏脂代谢中的作用及调控机制研究，横向项目，2022.4-2024.4，主持，在研

基于微环境的肿瘤免疫治疗研究，永利科技创新平台建设项目，2022.11-2024.12，参与，在研

结合拉曼光谱技术研究RNF8基因对脂代谢的调控机制，甘肃省自然科学基金，2021.11-2023.11，主持，结项

共焦拉曼光谱仪在检测重金属镉所致肾损伤中的应用，永利中央高校定向探索项目，2018.1-2019.12，主持，结项