睡眠觉醒中枢调控机制和睡眠疾病

情绪中枢调控机制

科研项目

1. 神经肽S及受体系统经杏仁核抗焦虑样行为与睡眠障碍的作用及其机制，国家自然科学青年基金项目（82001396），主持，2021.01-2023.12；

2. 脑内大麻素1型（CB₁）受体配体VD-HPα抗焦虑及睡眠障碍的作用，甘肃省青年科技基金（20JR5RA228），主持，2020.11-2022.10；

3. 薰衣草精油及其有效促眠成分经嗅觉的作用机制与神经环路，国家自然科学基金面上项目（31872770），参与，2019.01-2022.12；

4. 睡眠觉醒发育及生命早期REM睡眠的调节和功能，国家自然科学基金面上项目（81771426），参与，2018.01-2021.12；

5. 丙泊酚经外侧缰核抗抑郁样行为与睡眠障碍的作用和机制，中央高校基本科研业务费项目（lzujbky-2021-39），主持，2021.01-2022.12；

6. 内源性肽类大麻素VD-HPα及其受体系统对睡眠觉醒的调控作用，中央高校基本科研业务费项目（lzujbky-2018-25），主持，2018.01-2019.12。

学术论文

1.Xie JF, Wang LX, Ren WT, Wang C, Gao JX, Chen HL, Zhao XQ, Ren YL, Xie YP, Shao YF, Hou YP. An α-hemoglobin-derived peptide (m)VD-hemopressin (α) promotes NREM sleep via the CB1 cannabinoid receptor. Front Pharmacol. 2023;14:1213215

2.Gao JX, Yan G, Li XX, Xie JF, Spruyt K, Shao YF, Hou YP. The Ponto-Geniculo-Occipital (PGO) Waves in Dreaming: An Overview. Brain Sci. 2023;13(9):1350.

3.Chen HL, Gao JX, Chen YN, Xie JF, Xie YP, Spruyt K, Lin JS, Shao YF, Hou YP. Rapid Eye Movement Sleep during Early Life: A Comprehensive Narrative Review. Int J Environ Res Public Health. 2022;19(20):13101.

4.Chen YN, Zheng X, Chen HL, Gao JX, Li XX, Xie JF, Xie YP, Spruyt K, Shao YF, Hou YP. Stereotaxic atlas of the infant rat brain at postnatal days 7-13. Front Neuroanat. 2022;16:968320.

5.Wang C, Xin L, Cai CC, Cong CY, Xie JF, Kong XP, Dong CY, Li J, Cui GF, Chen HL, Ren YL, Shao YF, Hou YP. Neuropeptide S Displays as a Key Neuromodulator in Olfactory Spatial Memory. Chem Senses. 2020;45(3):195-202.

6.Cui GF, Hou M, Shao YF, Chen HL, Gao JX, Xie JF, Chen YN, Cong CY, Dai FQ, Hou YP. A Novel Continuously Recording Approach for Unraveling Ontogenetic Development of Sleep-Wake Cycle in Rats. Front Neurol. 2019;10:873.

7.Xie JF, Shao YF, Wang HL, Wang, C, Cui GF, Kong XP, Wang LX, Chen YN, Cong CY, Chen HL, Hou YP. Neuropeptide S counteracts paradoxical sleep deprivation-induced anxiety-like behavior and sleep disturbance. Front Cell Neurosci 2018; 12:64.

8.Xie JF, Fan K, Wang, C, Xie P, Hou M, Xin, L, Cui GF, Wang LX, Shao YF, Hou YP. Inactivation of the tuberomammillary nucleus by GABAA receptor agonist promotes slow wave sleep in freely moving rats and histamine-treated rats. Neurochem Res 2017; 42:2314-2325.

9.Kong XP, Wang C, Xie JF, Zhao P, Dai LR, Shao YF, Lin JS, Hou YP. Neuropeptide S reduces propofol- or ketamine- induced slow wave states through activation of cognate receptors in the rats. Neuropeptides 2017; 63:59-66.

10.Shao YF, Wang C, Xie JF, Kong XP, Xin L, Dong CY, Li J, Ren WT, Hou YP. Neuropeptide S ameliorates olfactory spatial memory impairment induced by scopolamine and MK801 through activation of cognate receptor-expressing neurons in the subiculum complex. Brain Struct Funct 2016; 221:3327-3336.

11.Shao YF*, Xie JF*, Ren YX, Wang C, Kong XP, Zong XJ, Fan LL, Hou YP. The inhibitory effect of botulinum toxin type A on rat pyloric smooth muscle contractile response to substance P in vitro. Toxins 2015; 7:4143-4156.（*Co-first author）

12.Hou M, Xie JF, Kong XP, Zhang Y, Shao YF, Wang C, Ren WT, Cui GF, Xin L, Hou YP. Acupoint injection of onabotulinumtoxin A for migraines. Toxins 2015; 7:4442-4454.

专利

1. 侯一平，崔光富，邵玉峰，解俊樊，王灿，陈雨侬，丛超宇，陈海林，高进贤，代丰秋，辛乐，王琳欣，蔡晨晨，郑欣. 一种动物睡眠剥夺装置，2018.12.06，中国，ZL2018 2 2045010.3.（实用新型专利）

2. 侯一平，邵玉峰，赵鹏，李婧，董朝玉，解俊樊，王灿，王海亮，戴丽蓉.一种嗅觉测试仪，2015.12.23，中国，ZL 2013 1 0341704.0.（发明专利）

3. 侯一平，邵玉峰，赵鹏，李婧，董朝玉，解俊樊，王灿，王海亮，戴丽蓉.一种红外探头，2014.1，中国，ZL 201320481383.X.（实用新型专利）